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Within relatively short time since its emergence, COVID-19 pandemic has attracted impressive academic attention. This chapter in its modest complement of existing studies focused on artisans' disposition and adherence to preventive measures of coronavirus disease in Osun State, Nigeria. The participants according to its findings demonstrated their knowledge of public health advice for controlling COVID-19 such as maintaining social distancing, using face masks in public spaces and adhering to personal hygiene measures. It further revealed that these artisans sourced for ‘perceived’ alternatives public health measures that their financial situation could accommodate and violated the strict lockdown regulations introduced by the government due to inherent economic rewards from going to their places of works. These thus exposed the poor investment profiles of most African nations as well as unhealthy institutional capacity, which cannot carry people along with government policies. A situation of this nature will have untoward effects on social fabric of the society and overall developmental processes.